Biosynthesis of the cancer-associated sialyl-Lea antigen.
نویسندگان
چکیده
منابع مشابه
The discovery, biology, and drug development of sialyl Lea and sialyl Lex.
The discoveries of sialylated, fucosylated lacto-, and neolacto-type carbohydrate structures were accomplished with the aid of analytical methods and monoclonal antibodies such as the immunostaining of thin layer chromatograms. Based on the use of such antibodies, these structures, notably sialyl Le(a) and sialyl Le(x), were demonstrated to be highly expressed in many malignant cancers. A diagn...
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Human blood group A, B, H, Ii, Le(a) and Le(b) antigens and their determinants expressed on ovarian cyst glycoproteins have been studied for over five decades. However, little is known about sialyl Le(x) and sialyl Le(a) glycotopes, which play essential roles in normal immunity, inflammation, and cancer cell metastasis. Furthermore, Le(x) and Le(y) were classified as glycotopes of unknown genes...
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15 صفحه اولRole of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
The Sialyl-Tn antigen (Neu5Acalpha2-6GalNAc-O-Ser/Thr) is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis. We characterized two human sialyltransferases, CMP-Neu5Ac:GalNAc-R alpha2,6-sialyltransferase (ST6GalNAc)-I and ST6GalNAc-II, that are candidate enzymes for Sialyl-Tn synthases. We expressed soluble recombinant hST6GalNAc-I an...
متن کاملBiosynthesis and expression of the Sd and sialyl Lewis x antigens in normal and cancer colon
The carbohydrate determinants Sd and sialyl Lewis x (sLex) both result from substitution of an a2,3-sialylated type 2 chain: the first with an N-acetylgalactosamine (GalNAc) b1,4-linked to Gal and the second by an a1,3linked fucose on N-acetylglucosamine. The Sd antigen is synthesized by Sd b1,4-N-acetylgalactosaminyltransferase II (b4GalNAcT-II), which is downregulated in colon cancer, whereas...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)39378-x